The coculture of marine red algal-derived endophytic fungi Aspergillus terreus EN-539 and Paecilomyces lilacinus EN-531 induced the production of a new terrein derivative, namely asperterrein (1) and a known dihydroterrein (2), which were not detected in the axenic cultures of both strains. The production of the known secondary metabolites terrein (3), butyrolactone I (4), and dankasterone (6), derived from A. terreus EN-539, were depressed significantly in the coculture. Compounds 1-3 exhibited inhibitory activity against Alternaria brassicae, Escherichia coli, Physalospora piricola, and Staphylococcus aureus with MIC values ranging from 4 to 64 μg ml-1.

中文翻译：

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与共生真菌淡紫色拟青霉菌EN-531共培养的海洋红色藻类内生真菌曲霉曲霉EN-539诱导产生的海藻糖蛋白。

海洋红色藻类内生真菌EN-539和淡紫色拟青霉EN-531的共培养诱导了新的Terrein衍生物的产生，即Asperterrein（1）和已知的二氢terrein（2），这在先天性真菌中未检测到。两种菌株的培养。共培养显着抑制了衍生自土壤曲霉EN-539的已知次生代谢产物terrein（3），丁内酯I（4）和dankasterone（6）的产生。化合物1-3表现出对交链孢霉，大肠埃希氏菌，皮氏菌和金黄色葡萄球菌的抑制活性，MIC值为4至64μgml-1。