Respiratory syncytial virus (RSV) infection is epidemiologically linked to asthma. During RSV infection, IL‐33 is elevated and promotes immune cell activation, leading to the development of asthma. However, which immune cells are responsible for triggering airway hyperreactivity (AHR), inflammation and eosinophilia remained to be clarified. We aimed to elucidate the individual roles of IL‐33‐activated innate immune cells, including ILC2s and ST2+ myeloid cells, in RSV infection‐triggered pathophysiology.

中文翻译：

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肺 IL-33 协调先天免疫细胞介导 RSV 诱发的气道高反应性和嗜酸性粒细胞增多

呼吸道合胞病毒 (RSV) 感染在流行病学上与哮喘有关。在 RSV 感染期间，IL-33 升高并促进免疫细胞活化，导致哮喘的发展。然而，哪些免疫细胞负责触发气道高反应性 (AHR)、炎症和嗜酸性粒细胞增多仍有待澄清。我们旨在阐明 IL-33 激活的先天免疫细胞（包括 ILC2 和 ST2+ 骨髓细胞）在 RSV 感染触发的病理生理学中的个体作用。