In this research, we synthesized and evaluated for in vitro antimicrobial activity a new series of hydrazide-hydrazones obtained from 5-nitrofuran-2-carboxylic acid. New compounds were identified and characterized by spectral methods (1 H NMR and 13 C NMR). All tested hydrazide-hydrazones proved to be promising antimicrobial agents. Antimicrobial activity and antifungal activity of new derivatives of 5-nitrofuran-2-carboxylic acid were revealed in many cases to be higher than the activity of reference substances (nitrofurantoin, cefuroxime and ampicillin).

中文翻译：

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有希望的抗菌剂的合成：5-硝基呋喃-2-羧酸的酰肼-azo。

在这项研究中，我们合成并评估了由5-硝基呋喃-2-羧酸制得的一系列新的酰肼-azo类化合物的体外抗菌活性。通过光谱方法（1 H NMR和13 C NMR）鉴定并表征了新化合物。所有测试过的酰肼-均被证明是有前途的抗菌剂。在许多情况下，发现5-硝基呋喃-2-羧酸新衍生物的抗菌活性和抗真菌活性高于参考物质（硝基呋喃妥因，头孢呋辛和氨苄青霉素）的活性。