Population-based health registries can be valuable resources for public health research, particularly for studying rare diseases and long-term health outcomes, where more traditional observational and experimental designs often have insufficient sample size or follow-up time to adequately address the research question(s) of interest. In this issue, Tith et al¹ demonstrate the utility of one such health registry for asking questions that are difficult to answer using more traditional study designs. Using hospitalization records for Quebec, Canada, from 2006 to 2018, they found that women who had been hospitalized for bulimia nervosa had higher incidence rates of cardiovascular disease (CVD) and death than women without bulimia who had experienced a pregnancy-related hospitalization. This research highlights the potential strength of registry data for informing interventions to enhance public health. Here, we offer thoughts on how to design and interpret registry-based studies to enhance validity.

以人群为基础的健康登记册可以成为公共卫生研究的宝贵资源，特别是对于研究罕见疾病和长期健康结果而言，在传统的观察和实验设计中，往往没有足够的样本量或足够的随访时间来充分解决研究问题（特别是对稀有疾病和长期健康结果的研究）（ s）感兴趣。在本期中，Tith等人¹演示了这样一个健康注册表的实用性，可以用更传统的研究设计来提出难以回答的问题。他们使用2006年至2018年加拿大魁北克的住院记录，发现因神经性贪食症住院的妇女比没有因妊娠而住院的无贪食症的妇女有更高的心血管疾病（CVD）和死亡发生率。这项研究强调了注册表数据在通知干预措施以增强公共卫生方面的潜在实力。在这里，我们提供有关如何设计和解释基于注册表的研究以提高有效性的想法。