OBJECTIVE Describe renal function of preterm infants <29 weeks of gestational age (GA) with twin-twin transfusion syndrome (TTTS) who received laser therapy. DESIGN Retrospective analysis of premature TTTS compared with dichorionic-diamniotic (di-di) twins from 2006 to 2015. Primary outcome was biomarkers of renal injury. RESULTS Thirty-three TTTS-laser and 101 di-di newborns with similar GA at birth (26.4 ± 1.4 vs 26.9 ± 1.6 weeks, p = 0.07) were included. Creatinine and urea levels were higher in TTTS-laser group at day of life (DOL) 2-7 (123.5 ± 12.4 vs 75.8 ± 2 μmol/L, p = 0.0001 and 11.9 ± 1.1 mmol/L vs 8.7 ± 0.3 mmol/L, p = 0.0001) and DOL 8-14, (98.1 ± 14.2 vs 64.8 ± 2.3 μmol/L, p = 0.0001 and 9.1 ± 1.2 vs 5.4 ± 0.3 mmol/L, p = 0.0001). There was a significant effect of TTTS status on creatinine level at DOL 8-14. CONCLUSION In extremely preterm with TTTS treated by laser, biomarkers of renal function were higher compared with di-di twins in the first 2 weeks of life.

中文翻译：

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患有和不患有双胎输血综合征的极早产儿的肾功能标记物。

目的描述接受激光治疗的胎龄<29周的双胎输血综合征（TTTS）早产儿（GA）的肾功能。设计回顾性分析2006年至2015年早产TTTS与双绒二胎（di-di）双胞胎的比较。主要结局是肾损伤的生物标志物。结果纳入了33例出生时GA相似的TTTS激光和101例di-di新生儿（26.4±1.4对26.9±1.6周，p = 0.07）。每日生活（DOL）2-7时，TTTS-激光组的肌酐和尿素水平较高（123.5±12.4 vs 75.8±2μmol/ L，p = 0.0001和11.9±1.1 mmol / L vs 8.7±0.3 mmol / L ，p ＝ 0.0001）和DOL 8-14（98.1±14.2vs 64.8±2.3μmol/ L，p ＝ 0.0001和9.1±1.2vs 5.4±0.3mmol / L，p ＝ 0.0001）。在DOL 8-14中，TTTS状态对肌酐水平有显着影响。