A water-soluble fluorine magnetic resonance spectroscopy host–guest probe, P(HPA-co-AdamCF₃A), was successfully constructed from the facile synthesis of a bifunctional monomer via a quantitative Passerini reaction. Supramolecular complexation with (2-hydroxypropyl)-β-cyclodextrin promoted a change in the chemical environment, leading to modulation of both the relaxation properties as well as chemical shift of the fluorine moieties. This change was used to probe the supramolecular interaction by ¹⁹F MRI spectroscopy and give insight into fluorine probe formulation. This work provides a fundamental basis for an ¹⁹F MR imaging tracer capable of assessing host–guest inclusion and a potential model to follow the fate of a drug delivery system in vivo.

中文翻译：

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基于Passerini双功能单体的超分子氟磁共振光谱探针聚合物

通过定量 Passerini 反应轻松合成双功能单体，成功构建了水溶性氟磁共振光谱主客体探针 P(HPA- co -AdamCF _{3 A)。}与 (2-羟丙基) -β-环糊精的超分子络合促进了化学环境的变化，从而调节了弛豫特性以及氟部分的化学位移。这种变化用于通过¹⁹ F MRI 光谱探测超分子相互作用，并深入了解氟探针的配方。这项工作为¹⁹F MR 成像示踪剂能够评估主客体的包含情况，以及跟踪体内药物输送系统命运的潜在模型。