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Oregonensins A and B, new meroterpenoids from the culture broth of Ganoderma oregonense and their antioxidant activity.
The Journal of Antibiotics ( IF 3.3 ) Pub Date : 2019-10-15 , DOI: 10.1038/s41429-019-0248-y
Ji-Yul Kim 1 , E-Eum Woo 1 , Lee Su Ha 1 , Young-Hee Kim 1 , In-Kyoung Lee 1 , Bong-Sik Yun 1
Affiliation  

Two new meroterpene derivatives (1 and 2), together with three known compounds (3-5) were isolated from the culture broth of fungus Ganoderma oregonense. Chemical structures of compounds 1-5 were determined using spectroscopic methods. All compounds were tested for 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging efficacy. Compound 1 exhibited significant antioxidant activities with IC50 values of 31.2 and 65.4 μM in the ABTS and DPPH radical scavenging activities, respectively.

中文翻译:

Oregonensins A和B,来自灵芝培养液的新甲氧类萜及其抗氧化活性。

从真菌灵芝的培养液中分离了两种新的美萜烯衍生物(1和2)以及三种已知的化合物(3-5)。使用光谱法确定化合物1-5的化学结构。测试所有化合物的2,2'-叠氮基双(3-乙基苯并噻唑啉-6-磺酸)(ABTS)和1,1-二苯基-2-吡啶并肼基(DPPH)清除自由基的功效。化合物1在ABTS和DPPH自由基清除活性中表现出显着的抗氧化活性,IC50值分别为31.2和65.4μM。
更新日期:2020-01-16
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