The K⁺/Cl⁻ cotransporter KCC2 is a molecular switch between excitatory and inhibitory effects of GABAergic inputs into neurons. In a pair of exciting studies, Watanabe et al. and Pisella et al. elucidate the role of KCC2 dephosphorylation in this process and reveal its consequences for neurodevelopment and nervous system pathology.

中文翻译：

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调节调节器：KCC2在两个特定位点的磷酸化对于神经发育至关重要

在K ⁺ /氯^-协同转运蛋白KCC2是GABA能输入兴奋性和抑制效果为神经元之间的分子开关。在一项激动人心的研究中，渡边等人。和Pisella等。阐明了KCC2去磷酸化在此过程中的作用，并揭示了其对神经发育和神经系统病理学的影响。