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Graphene-based biosensors for the detection of prostate cancer protein biomarkers: a review
BMC Chemistry ( IF 4.6 ) Pub Date : 2019-09-03 , DOI: 10.1186/s13065-019-0611-x
Li Xu , Yanli Wen , Santosh Pandit , Venkata R. S. S. Mokkapati , Ivan Mijakovic , Yan Li , Min Ding , Shuzhen Ren , Wen Li , Gang Liu

Prostate cancer (PC) is the sixth most common cancer type in the world, which causes approximately 10% of total cancer fatalities. The detection of protein biomarkers in body fluids is the key topic for the diagnosis and prognosis of PC. Highly sensitive screening of PC is the most effective approach for reducing mortality. Thus, there are a growing number of literature that recognizes the importance of new technologies for early diagnosis of PC. Graphene is playing an important role in the biosensor field with remarkable physical, optical, electrochemical and magnetic properties. Many recent studies demonstrated the potential of graphene materials for sensitive detection of protein biomarkers. In this review, the graphene-based biosensors toward PC analysis are mainly discussed in two groups: Firstly, novel biosensor interfaces were constructed through the modification of graphene materials onto sensor surfaces. Secondly, ingenious signal amplification strategies were developed using graphene materials as catalysts or carriers. Graphene-based biosensors have exhibited remarkable performance with high sensitivities, wide detection ranges, and long-term stabilities.

中文翻译:

基于石墨烯的生物传感器可检测前列腺癌蛋白质生物标志物:综述

前列腺癌(PC)是世界上第六大最常见的癌症类型,约占总癌症死亡人数的10%。体液中蛋白质生物标志物的检测是PC诊断和预后的关键主题。高度敏感的PC筛查是降低死亡率的最有效方法。因此,越来越多的文献认识到新技术对PC的早期诊断的重要性。石墨烯在生物传感器领域起着重要的作用,具有显着的物理,光学,电化学和磁性特性。最近的许多研究表明,石墨烯材料具有潜在性地检测蛋白质生物标志物的潜力。在这篇综述中,针对PC分析的基于石墨烯的生物传感器主要分为两类:第一,通过将石墨烯材料修饰到传感器表面上,构建了新颖的生物传感器界面。其次,利用石墨烯材料作为催化剂或载体开发了巧妙的信号放大策略。基于石墨烯的生物传感器具有出色的性能,具有高灵敏度,宽检测范围和长期稳定性。
更新日期:2019-09-03
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