BACKGROUND To this day, empirical data suggests that zinc has important roles in matrix synthesis, bone turnover, and mineralization and its beneficial effects on bone could be mediated through different mechanisms. The influence of zinc on bone turnover could be facilitated via regulating RANKL/RANK/OPG pathway in bone tissue. Therefore, the aim of the study was to conduct a review to investigate the possible effect of the zinc mediated bone remodeling via RANKL/RANK/OPG pathway. METHODS A comprehensive systematic search was performed in MEDLINE/PubMed, Cochrane Library, SCOPUS, and Google Scholar to explore the studies investigating the effect of zinc as a bone remodeling factor via RANKL/RANK/OPG pathway regulation. Subsequently, the details of the pathway and the impact of zinc supplements on RANKL/RANK/OPG pathway regulation were discussed. RESULTS The pathway could play an important role in bone remodeling and any imbalance between RANKL/RANK/OPG components could lead to extreme bone resorption. Although the outcomes of some studies are equivocal, it is evident that zinc possesses protective properties against bone loss by regulating the RANKL/RANK/OPG pathway. There are several experiments where zinc supplementation resulted in upregulation of OPG expression or decreases RANKL level. However, the results of some studies oppose this. CONCLUSION It is likely that sufficient zinc intake will elicit positive effects on bone health by RANKL/RANK/OPG regulation. Although the outcomes of a few studies are equivocal, it seems that zinc can exert the protective properties against bone loss by suppressing osteoclastogenesis via downregulation of RANKL/RANK. Additionally, there are several experiments where zinc supplementation resulted in upregulation of OPG expression. However, the results of limited studies oppose this. Therefore, aside from the positive role zinc possesses in preserving bone mass, further effects of zinc in RANKL/RANK/OPG system requires further animal/human studies.

中文翻译：

---

锌补充剂和骨骼健康：RANKL-RANK轴作为治疗靶标的作用。

背景技术迄今为止，经验数据表明锌在基质合成，骨转换和矿化中具有重要作用，并且其对骨骼的有益作用可以通过不同的机制介导。锌对骨转换的影响可以通过调节骨组织中的RANKL / RANK / OPG途径来促进。因此，该研究的目的是进行综述，以研究锌介导的通过RANKL / RANK / OPG途径介导的骨重塑的可能作用。方法在MEDLINE / PubMed，Cochrane Library，SCOPUS和Google Scholar中进行了全面的系统搜索，以探索研究锌作为通过RANKL / RANK / OPG途径调控的骨重塑因子的作用的研究。随后，讨论了途径的细节以及锌补充剂对RANKL / RANK / OPG途径调控的影响。结果该途径可能在骨骼重塑中起重要作用，而RANKL / RANK / OPG成分之间的任何不平衡都可能导致骨骼的极端吸收。尽管一些研究的结果是模棱两可的，但很明显锌通过调节RANKL / RANK / OPG途径具有防止骨质流失的保护特性。有几个实验，其中补锌导致OPG表达上调或降低RANKL水平。但是，一些研究的结果与此相反。结论通过RANKL / RANK / OPG调节，摄入足够的锌可能对骨骼健康产生积极影响。尽管一些研究的结果是模棱两可的，但锌似乎可以通过下调RANKL / RANK抑制破骨细胞生成而发挥保护骨质的作用。此外，有几个实验中，补锌导致OPG表达上调。但是，有限的研究结果却与此相反。因此，除了锌在保持骨骼质量方面的积极作用外，锌在RANKL / RANK / OPG系统中的进一步作用还需要动物/人体研究。