Transition metal-catalysed bioorthogonal reactions are severely hindered in biomedical applications, mainly due to a lack of target specificity. Now, research shows that a trojan exosome vesicle can deliver a palladium catalyst specifically to progenitor cells for bioorthogonal catalysis, allowing localized prodrug activation.

中文翻译：

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外来体可用于细胞靶向的生物正交催化

过渡金属催化的生物正交反应在生物医学应用中受到严重阻碍，这主要是由于缺乏靶标特异性。现在，研究表明，特洛伊木马外泌体囊泡可以将钯催化剂专门递送给祖细胞以进行生物正交催化，从而实现局部前药活化。