BACKGROUND Whether and to what extent leisure-time physical activity at the recommended levels of 150-min moderate activity is associated with survival in people with cardiometabolic multimorbidity and depression is unknown. METHODS UK Biobank participants were classified into groups: (i) no disease; (ii) diabetes; (iii) cardiovascular disease (CVD); (iv) depression; (v) diabetes and CVD; (vi) diabetes and depression; (vii) CVD and depression; (viii) diabetes, CVD and depression. Leisure-time physical activity was categorized as active (meeting recommendations) or inactive. Survival models were applied to estimate life expectancy. RESULTS A total of 480 940 participants were included (median age, 58 years; 46% men; 95% white), of whom 74% with cardiometabolic multimorbidity and depression were inactive. During a mean follow-up of 7 years, 11 006 deaths occurred. At age of 45 years, being physically active was associated with 2.34 (95% confidence interval: 0.93, 3.54) additional years of life compared with being inactive in participants with diabetes; corresponding estimates were 2.28 (1.40, 3.16) for CVD; 2.15 (0.05, 4.26) for diabetes and CVD; and 1.58 (1.27, 1.89) for no disease. Participants with a combination of diabetes, CVD and depression, being active was associated with 6.81 (-1.50, 15.31) additional years compared with being inactive; corresponding estimates were 3.07 (-2.46, 8.59) for diabetes and depression; 2.34 (-1.24, 5.91) for CVD and depression; and 0.80 (-0.46, 2.05) for depression. A similar pattern was found at 65 years. CONCLUSIONS Meeting the recommended level of physical activity was associated with a longer life expectancy in people with cardiometabolic multimorbidity but not in those with depression.

中文翻译：

---

患有心脏代谢异常和抑郁症的人的休闲运动和预期寿命。

背景技术在建议的150分钟中等活动水平上，休闲运动是否与心脏代谢性多发病和抑郁症患者的生存有关，以及在何种程度上与生存有关。方法英国生物库参与者分为以下几类：（i）没有疾病；（ii）糖尿病；（iii）心血管疾病；（iv）抑郁症；（v）糖尿病和心血管疾病；（vi）糖尿病和抑郁症；（vii）心血管疾病和抑郁症；（viii）糖尿病，CVD和抑郁症。业余时间的体育活动分为活跃的（会议建议）或不活跃的。生存模型被用于估计预期寿命。结果共纳入480 940名参与者（中位年龄58岁；男性46％；白人95％），其中74％患有心脏代谢性多发病和抑郁的患者无效。在平均7年的随访期间，发生11 006人死亡。在45岁时，与不参加糖尿病运动的人相比，参加运动会增加2.34（95％置信区间：0.93，3.54）的寿命。CVD的相应估计值为2.28（1.40，3.16）；糖尿病和CVD为2.15（0.05，4.26）；没有疾病则为1.58（1.27，1.89）。与非活动状态相比，合并有糖尿病，心血管疾病和抑郁症的参与者活动时间增加了6.81（-1.50，15.31）年。糖尿病和抑郁症的相应估计为3.07（-2.46，8.59）；2.34（-1.24，5.91）用于CVD和抑郁症; 抑郁症则为0.80（-0.46，2.05）。在65岁时也发现了类似的模式。