Regulatory T (Treg) cells expressing the X-chromosome-encoded transcription factor Foxp3 represent a specialized immunosuppressive lineage with a well-recognized, essential function in preventing fatal autoimmunity and inflammation. Recent studies revealed that Treg cells can also exert systemic effects on metabolism and partake in tissue repair, suggesting a dual role for these cells in serving and protecting tissues. Here, we review multiple means by which Treg cells support tissue function and organismal homeostasis.

中文翻译：

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调节性T细胞在组织病理生理和代谢中的作用。

表达X染色体编码的转录因子Foxp3的调节性T（Treg）细胞代表一种特殊的免疫抑制谱系，具有公认的基本功能，可以防止致命的自身免疫和炎症。最近的研究表明，Treg细胞还可以对新陈代谢发挥全身作用，参与组织修复，提示这些细胞在服务和保护组织中起着双重作用。在这里，我们审查Treg细胞支持组织功能和机体稳态的多种手段。