The Althea Officinalis (AO) extract is well known as a traditional herbal drug for its wound healing ability owing to the anti‐inflammatory and antimicrobial properties. Furthermore, its mucilaginous properties provide moisturizing and nutritional effects on skin cell proliferation. Therefore, AO extract can be applied in the temporary skin substitute for the ability to expedite the therapy duration. In this study, different concentrations of AO extract (0, 5, 10, 15, and 20 wt %) were incorporated into the nanofibrous scaffolds to study their potential for the skin tissue repairing. The desired scaffolds were prepared by electrospinning the blend of poly(ε‐caprolactone) and gelatin as a synthesized and natural polymer. The electrospun nanofibers were characterized by SEM, FTIR, DSC, TGA, tensile, AO extract release, and cellular culture tests. This study proposed incorporating the AO extract into the nanofibrous scaffolds for accelerating the skin tissue repairing and the optimized amount of AO extract as about 15% was introduced for offering the most desirable electrospun scaffolds for this application. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48587.

中文翻译：

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制备具有木槿花的电纺纳米纤维支架，可用于皮肤组织工程的潜在应用

Althea Officinalis（AO）提取物由于具有抗炎和抗菌特性，具有伤口愈合能力，因此被称为传统草药。此外，其粘液性对皮肤细胞增殖提供保湿和营养作用。因此，AO提取物可用于临时皮肤替代品，以加快治疗时间。在这项研究中，将不同浓度的AO提取物（0、5、10、15和20 wt％）掺入纳米纤维支架中，以研究其在皮肤组织修复中的潜力。通过静电纺制聚（ε的共混物）来制备所需的脚手架己内酯）和明胶作为合成的天然聚合物。通过SEM，FTIR，DSC，TGA，拉伸，AO提取物释放和细胞培养测试对电纺纳米纤维进行了表征。这项研究提出将AO提取物掺入纳米纤维支架中以促进皮肤组织修复，并引入AO提取物的最佳量（约15％）以提供该应用所需的最理想的电纺支架。分级为4 +©2019 Wiley Periodicals，Inc.J.Appl。Polym。科学 2020，137，48587。