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Cell Motility and Cytokinesis: From Mysteries to Molecular Mechanisms in Five Decades.
Annual Review of Cell and Developmental Biology ( IF 11.3 ) Pub Date : 2019-08-08 , DOI: 10.1146/annurev-cellbio-100818-125427
Thomas D Pollard 1
Affiliation  

This is the story of someone who has been fortunate to work in a field of research where essentially nothing was known at the outset but that blossomed with the discovery of profound insights about two basic biological processes: cell motility and cytokinesis. The field started with no molecules, just a few people, and primitive methods. Over time, technological advances in biophysics, biochemistry, and microscopy allowed the combined efforts of scientists in hundreds of laboratories to explain mysterious processes with molecular mechanisms that can be embodied in mathematical equations and simulated by computers. The success of this field is a tribute to the power of the reductionist strategy for understanding biology.

中文翻译:

细胞动力和细胞分裂:从奥秘到分子机制的五个世纪。

这是一个有幸在研究领域工作的人的故事,该研究一开始基本上一无所知,但随着对两种基本生物学过程(细胞运动性和胞质分裂)的深刻见解而蓬勃发展。这个领域始于没有分子,只有几个人和原始方法。随着时间的流逝,生物物理学,生物化学和显微镜技术的进步,使数百个实验室的科学家共同努力,用分子机理解释了神秘的过程,这些分子机理可以用数学方程式体现,也可以用计算机模拟。该领域的成功是对简化论理解生物学的力量的贡献。
更新日期:2020-04-21
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