Endocytosis has long been identified as a key cellular process involved in bringing in nutrients, in clearing cellular debris in tissue, in the regulation of signaling, and in maintaining cell membrane compositional homeostasis. While clathrin-mediated endocytosis has been most extensively studied, a number of clathrin-independent endocytic pathways are continuing to be delineated. Here we provide a current survey of the different types of endocytic pathways available at the cell surface and discuss a new classification and plausible molecular mechanisms for some of the less characterized pathways. Along with an evolutionary perspective of the origins of some of these pathways, we provide an appreciation of the distinct roles that these pathways play in various aspects of cellular physiology, including the control of signaling and membrane tension.

中文翻译：

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被宠坏的选择：细胞表面的多种内吞途径发挥作用。

内吞作用长期以来一直被认为是一个关键的细胞过程，涉及引入营养物质、清除组织中的细胞碎片、调节信号传导和维持细胞膜组成的稳态。虽然网格蛋白介导的内吞作用已得到最广泛的研究，但仍在继续描述许多不依赖网格蛋白的内吞途径。在这里，我们提供了对细胞表面可用的不同类型的内吞途径的当前调查，并讨论了一些特征较少的途径的新分类和合理的分子机制。除了对其中一些途径起源的进化观点外，我们还提供了对这些途径在细胞生理学各个方面所起的不同作用的认识，包括信号传导和膜张力的控制。