Phospholipids are synthesized primarily within the endoplasmic reticulum and are subsequently distributed to various subcellular membranes to maintain the unique lipid composition of specific organelles. As a result, in most cases, the steady-state localization of membrane phospholipids does not match their site of synthesis. This raises the question of how diverse lipid species reach their final membrane destinations and what molecular processes provide the energy to maintain the lipid gradients that exist between various membrane compartments. Recent studies have highlighted the role of inositol phospholipids in the nonvesicular transport of lipids at membrane contact sites. This review attempts to summarize our current understanding of these complex lipid dynamics and highlights their implications for defining future research directions.

中文翻译：

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内质网和其他细胞器之间接触部位的脂质动力学。

磷脂主要在内质网内合成，然后分布到各种亚细胞膜上，以维持特定细胞器独特的脂质组成。结果，在大多数情况下，膜磷脂的稳态定位与它们的合成位点不匹配。这就提出了一个问题，即不同的脂质种类如何到达其最终的膜目的地，以及哪些分子过程提供了能量来维持存在于各个膜区室之间的脂质梯度。最近的研究强调了肌醇磷脂在膜接触部位脂质的非囊泡运输中的作用。这篇综述试图总结我们目前对这些复杂脂质动力学的理解，并强调它们对定义未来研究方向的影响。