Key Points Question Does providing a comprehensive set of essential medicines at no charge to primary care patients who have difficulty affording medicines improve treatment adherence? Findings In this randomized clinical trial of 786 primary care patients, free distribution of essential medicines vs usual access resulted in greater adherence to treatment with medicines (absolute risk difference, 11.6%). Control of type 1 and 2 diabetes was not significantly improved by free distribution of essential medicines (hemoglobin A1c, −0.38%), systolic blood pressure was reduced (−7.2 mm Hg), and low-density lipoprotein cholesterol levels were not affected (−2.3 mg/dL). Meaning Distributing essential medicines at no charge increased adherence to appropriately prescribed treatment with medicines and improved some disease-specific surrogate health outcomes.

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免费发放基本药物对治疗依从性的影响

要点 问题 向难以负担药物的初级保健患者免费提供一整套基本药物能否提高治疗依从性？结果 在这项对 786 名初级保健患者进行的随机临床试验中，基本药物的免费分发与常规获取相比，药物治疗的依从性更高（绝对风险差异为 11.6%）。免费分发基本药物（血红蛋白 A1c，-0.38%）并未显着改善 1 型和 2 型糖尿病的控制，收缩压降低（-7.2 mm Hg），低密度脂蛋白胆固醇水平未受影响（- 2.3 毫克/分升）。意义 免费分发基本药物可提高对适当处方药物治疗的依从性，并改善某些特定疾病的替代健康结果。