Risk of Zika microcephaly correlates with features of maternal antibodies.,Journal of Experimental Medicine

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Risk of Zika microcephaly correlates with features of maternal antibodies.
Journal of Experimental Medicine ( IF 15.3 ) Pub Date : 2019-08-14 , DOI: 10.1084/jem.20191061
Davide F Robbiani ₁ , Priscilla C Olsen _{2,

3} , Federico Costa _{4,

5} , Qiao Wang ₆ , Thiago Y Oliveira ₂ , Nivison Nery ₇ , Adeolu Aromolaran ₄ , Mateus S do Rosário ₈ , Gielson A Sacramento ₇ , Jaqueline S Cruz ₇ , Ricardo Khouri ₇ , Elsio A Wunder ₄ , Adriana Mattos ₈ , Bruno de Paula Freitas _{8,

9} , Manoel Sarno ₅ , Gracinda Archanjo ₈ , Dina Daltro ₈ , Gustavo B S Carvalho ₈ , Kleber Pimentel ₈ , Isadora C de Siqueira ₇ , João R M de Almeida ₅ , Daniele F Henriques ₁₀ , Juliana A Lima ₁₀ , Pedro F C Vasconcelos ₁₀ , Dennis Schaefer-Babajew ₂ , Stephanie A Azzopardi ₁₁ , Leonia Bozzacco ₁₁ , Anna Gazumyan ₂ , Rubens Belfort ₉ , Ana P Alcântara ₁₂ , Gustavo Carvalho ₁₂ , Licia Moreira ₁₂ , Katiaci Araujo ₁₃ , Mitermayer G Reis _{4,

5,

7} , Rebekah I Keesler ₁₄ , Lark L Coffey ₁₅ , Jennifer Tisoncik-Go _{16,

17,

18} , Michael Gale _{16,

17,

18,

19} , Lakshmi Rajagopal _{19,

20,

21} , Kristina M Adams Waldorf _{16,

17,

19,

22} , Dawn M Dudley ₂₃ , Heather A Simmons ₂₄ , Andres Mejia ₂₄ , David H O'Connor ₂₃ , Rosemary J Steinbach ₂₅ , Nicole Haese _{26,

27} , Jessica Smith ₂₇ , Anne Lewis ₂₈ , Lois Colgin ₂₆ , Victoria Roberts ₂₅ , Antonio Frias _{25,

29} , Meredith Kelleher ₂₅ , Alec Hirsch _{26,

27} , Daniel N Streblow _{26,

27} , Charles M Rice ₁₁ , Margaret R MacDonald ₁₁ , Antonio R P de Almeida ₅ , Koen K A Van Rompay _{14,

15} , Albert I Ko _{4,

7} , Michel C Nussenzweig _{1,

30}

Affiliation

Laboratory of Molecular Immunology, The Rockefeller University, New York, NY
Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT.
Faculdade de Medicina and Instituto da Saúde Coletiva, Universidade Federal da Bahia, Salvador, Bahia, Brazil.
Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Instituto Gonçalo Moniz, Fundação Oswaldo Cruz/MS, Salvador, Bahia, Brazil.
Hospital Geral Roberto Santos, Secretária da Saúde do Estado da Bahia, Salvador, Brazil.
Universidade Federal de São Paulo, São Paulo, Brazil.
Instituto Evandro Chagas, Ministério da Saúde Ananindeua, Pará, Brazil.
Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY.
Hospital Santo Amaro, Salvador, Bahia, Brazil.
Hospital Aliança, Salvador, Bahia, Brazil.
California National Primate Research Center, University of California, Davis, Davis, CA.
Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, Davis, CA.
Washington National Primate Research Center, Seattle, WA.
Center for Innate Immunity and Immune Disease, University of Washington, Seattle, WA.
Department of Immunology, University of Washington, Seattle, WA.
Department of Global Health, University of Washington, Seattle, WA.
Department of Pediatrics, University of Washington, Seattle, WA.
Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA.
Department of Obstetrics and Gynecology, University of Washington, Seattle, WA.
Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI.
Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI.
Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Beaverton, OR.
Division of Pathobiology and Immunology, Oregon National Primate Research Center, Beaverton, OR.
Vaccine and Gene Therapy Institute, Oregon Health and Science University, Portland, OR.
Pathology Services Unit, Division of Comparative Medicine, Oregon National Primate Research Center, Beaverton, OR.
Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR.
Howard Hughes Medical Institute, The Rockefeller University, New York, NY.

Zika virus (ZIKV) infection during pregnancy causes congenital abnormalities, including microcephaly. However, rates vary widely, and the contributing risk factors remain unclear. We examined the serum antibody response to ZIKV and other flaviviruses in Brazilian women giving birth during the 2015-2016 outbreak. Infected pregnancies with intermediate or higher ZIKV antibody enhancement titers were at increased risk to give birth to microcephalic infants compared with those with lower titers (P < 0.0001). Similarly, analysis of ZIKV-infected pregnant macaques revealed that fetal brain damage was more frequent in mothers with higher enhancement titers. Thus, features of the maternal antibodies are associated with and may contribute to the genesis of ZIKV-associated microcephaly.

中文翻译：

寨卡小头畸形的风险与母体抗体的特征有关。

怀孕期间感染寨卡病毒（ZIKV）会导致先天性异常，包括小头畸形。但是，费率差异很大，导致危险的因素尚不清楚。我们检查了2015-2016年暴发期间分娩的巴西女性对ZIKV和其他黄病毒的血清抗体反应。与滴度较低的婴儿相比，感染中度或较高的ZIKV抗体增强滴度的孕妇分娩小头畸形婴儿的风险更高（P <0.0001）。同样，对感染ZIKV的孕妇猕猴的分析表明，滴度更高的母亲对胎儿大脑的伤害更为频繁。因此，母体抗体的特征与ZIKV相关的小头畸形的发生有关并且可能对其做出贡献。

更新日期：2019-10-07

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