Antibody neutralization of a virus in vitro is often associated with protection against viral exposure in vivo, but the mechanisms operational in vivo are often unclear. By investigating a large number of antibodies, Earnest et al. (https://doi.org/10.1084/jem.20190736) show the importance of antibody effector function in neutralizing antibody protection against an emerging alphavirus in a mouse model.

中文翻译：

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病毒传播的抗体障碍。

病毒在体外的抗体中和作用通常与体内病毒暴露的防护有关，但在体内起作用的机制通常尚不清楚。通过研究大量的抗体，Earnest等人。（https://doi.org/10.1084/jem.20190736）显示了抗体效应子功能在中和小鼠模型中针对新兴甲病毒的抗体保护中的重要性。