Mullins et al. made a comment on our article (DOI: 10.1039/C9TX00002J) stating they noticed the omission of the one-bag, standard concentration protocol which is shared by several centers in North America when we discussed IV acetylcysteine protocols. In this reply we clarify that we did not include this methodology as it is a technical adaption of the way in which a 2-bag NAC regimen in administered and there is insufficient comparative data with other regimens.

中文翻译：

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ME Mullins，MC Yarema，MLA Sivilotti，M。Thompson，DA Algren，MC Beuhler和CP Holstege，Toxicol回答了“关于对乙酰氨基酚中毒的乙酰半胱氨酸：45年使用前景”的评论。Res。，2019，8，DOI：10.1039 / C9TX00158A

Mullins等。对我们的文章（DOI：10.1039 / C9TX00002J）进行了评论，指出他们注意到省略了一个袋子的标准浓度实验方案，当我们讨论静脉内乙酰半胱氨酸实验方案时，北美的几个中心都同意这样做。在此答复中，我们澄清说，我们没有包括这种方法，因为它是对2袋NAC方案的给药方式的技术适应，并且与其他方案的比较数据不足。