Amelioration of solid tumor hypoxia is one of the promising therapeutic strategies for malignant tumor ablation. In particular, reactive oxygen species (ROS)-induced apoptosis has been proved to be an efficient tumor therapeutic approach, relying on advanced drug delivery or rapid production of ROS in the tumor region. However, the ROS generation is severely limited by tumor hypoxia. Herein, a new nanostructure based on biodegradable mesoporous magnetic nanocubes (MMNCs) is designed for ROS self-generation and self-enhancement magnetic thermotherapy. Typically, vitamin c (Vc) locked in MMNCs with phase-change materials (PCM) could be triggered by hyperthermia under an alternating magnetic field (AMF), serving as an original source for ROS (H₂O₂) generation. In addition, the MMNCs possess Fenton reagent-like activity in an acidic environment for ROS self-enhancement, which causes severe damage to tumor cells. The multifunctional nanotheranostics exhibits remarkable hyperthermia and enhanced ROS synergistic therapy efficiency. Furthermore, the nanoplatform demonstrates good biodegradability under acidic tumor microenvironment conditions. This finding highlights the great potential of Vc loaded magnetic nanoparticle composites as efficient agents for tumor therapy. It opens an avenue for the design of nanoformulations with ROS self-generation and self-enhancement for overcoming tumor hypoxia.

中文翻译：

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ROS自生和缺氧自增强生物可降解磁性纳米治疗剂用于靶向肿瘤治疗

改善实体瘤缺氧是恶性肿瘤消融的有前途的治疗策略之一。特别地，已经证明活性氧（ROS）诱导的细胞凋亡是一种有效的肿瘤治疗方法，它依赖于肿瘤区域中先进的药物递送或ROS的快速产生。然而，ROS的产生受到肿瘤缺氧的严重限制。本文中，基于可生物降解的介孔磁性纳米立方体（MMNC）的新纳米结构被设计用于ROS自生和自我增强的磁热疗法。通常，通过相变材料（PCM）锁定在MMNC中的维生素c（Vc）可能在交变磁场（AMF）下由高温触发，这是ROS（H ₂ O ₂）的原始来源。） 一代。另外，MMNC在酸性环境中具有类似Fenton试剂的活性以用于ROS的自我增强，这会严重破坏肿瘤细胞。多功能纳米热疗剂显示出显着的热疗效果，并增强了ROS协同治疗效率。此外，纳米平台在酸性肿瘤微环境条件下表现出良好的生物降解性。这一发现凸显了载有Vc的磁性纳米颗粒复合材料作为肿瘤治疗有效药物的巨大潜力。它为设计具有ROS自生和自我增强功能以​​克服肿瘤缺氧的纳米制剂开辟了一条途径。