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Association between ambient air pollution and out-of-hospital cardiac arrest: are there potentially susceptible groups?
Journal of Exposure Science and Environmental Epidemiology ( IF 4.5 ) Pub Date : 2019-10-02 , DOI: 10.1038/s41370-019-0140-7
Fu-Jen Cheng,Kuan-Han Wu,Shih-Chiang Hung,Kuo-Hsin Lee,Chia-Wei Lee,Kun-Ying Liu,Ping-Chi Hsu

This study aimed to examine the association between air pollution and out-of-hospital cardiac arrest (OHCA), and the effects of underlying diseases. Between January 2015 and December 2016, data on particulate matter (PM)2.5 and other air pollutants in Kaohsiung City were collected, and an emergency medical service database was used for information on patients who experienced OHCA. Overall, 3566 patients were analyzed and subgroup analyses by sex, age, and preexisting morbidities were performed. Interquartile increments in PM2.5, PM10, and O3 levels on lag 1 and NO2 level on lag 3 were associated with increments of 10.8%, 11.3%, 6.2%, and 1.7% in OHCA incidence, respectively. Subgroup analyses showed that patients with diabetes (1.363; interaction p = 0.009), heart disease (1.612; interaction p = 0.001), and advanced age (≥70 years, 1.297; interaction p = 0.003) were more susceptible to NO2 on lag 3. Moreover, patients were more susceptible to O3 during the cold season (1.194; interaction p = 0.001). We found that PM2.5, PM10, NO2, and O3 may play an important role in OHCA events, and the effects vary by underlying condition, age and season.



中文翻译:

周围空气污染与院外心脏骤停之间的关联:是否存在潜在的易感人群?

这项研究旨在检查空气污染与院外心脏骤停(OHCA)以及潜在疾病的影响之间的关联。在2015年1月至2016年12月期间,收集了高雄市2.5颗粒物(PM)和其他空气污染物的数据,并使用了紧急医疗服务数据库来获取有关经历过OHCA的患者的信息。总共对3566例患者进行了分析,并按性别,年龄和既往发病率进行了亚组分析。滞后1和NO 2的PM 2.5,PM 10和O 3水平的四分位数增量滞后3的水平分别与OHCA发生率分别增加10.8%,11.3%,6.2%和1.7%有关。亚组分析显示,糖尿病患者(1.363;交互作用p  = 0.009),心脏病(1.612;交互作用p  = 0.001)和高龄患者(≥70岁,1.297;交互作用p  = 0.003)较易发生NO 2滞后3.此外,患者在寒冷季节更容易受到O 3的影响(1.194;相互作用p  = 0.001)。我们发现PM 2.5,PM 10,NO 2和O 3可能在OHCA事件中起重要作用,并且其影响随潜在条件,年龄和季节而变化。

更新日期:2019-10-03
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