RNA turnover and processing in bacteria are governed by the structurally divergent but functionally convergent RNA degradosome, and the mechanisms have been researched extensively in Gram-positive and Gram-negative bacteria. An emerging research field focuses on how bacterial viruses hijack all aspects of the bacterial metabolism, including the host machinery of RNA metabolism. This review addresses research on phage-based influence on RNA turnover, which can act either indirectly or via dedicated effector molecules that target degradosome assemblies. The structural divergence of host RNA turnover mechanisms likely explains the limited number of phage proteins directly targeting these specialized, host-specific complexes. The unique and nonconserved structure of DIP, a phage-encoded inhibitor of the Pseudomonas degradosome, illustrates this hypothesis. However, the natural occurrence of phage-encoded mechanisms regulating RNA turnover indicates a clear evolutionary benefit for this mode of host manipulation. Further exploration of the viral dark matter of unknown phage proteins may reveal more structurally novel interference strategies that, in turn, could be exploited for biotechnological applications.

中文翻译：

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Dip-a-Dee-Doo-Dah：噬菌体介导的协调协调的RNA代谢的记录。

细菌中的RNA转换和加工受结构差异性但功能趋同的RNA降解体的控制，并且对革兰氏阳性和革兰氏阴性细菌的机理已进行了广泛的研究。一个新兴的研究领域集中于细菌病毒如何劫持细菌代谢的所有方面，包括RNA代谢的宿主机制。这篇综述涉及基于噬菌体的RNA转化影响的研究，该研究可以间接起作用，也可以通过靶向降解体装配体的专用效应分子起作用。宿主RNA周转机制的结构差异可能解释了直接靶向这些专门的，宿主特异性复合物的噬菌体蛋白数量有限。噬菌体编码的假单胞菌降解体抑制剂DIP的独特且非保守结构，说明了这一假设。然而，调节RNA更新的噬菌体编码机制的自然发生表明这种宿主操纵模式具有明显的进化优势。对未知噬菌体蛋白的病毒暗物质的进一步探索可能揭示出结构上更为新颖的干扰策略，进而可以将其用于生物技术应用。