Influenza viruses are a leading cause of seasonal and pandemic respiratory illness. Influenza is a negative-sense single-stranded RNA virus that encodes its own RNA-dependent RNA polymerase (RdRp) for nucleic acid synthesis. The RdRp catalyzes mRNA synthesis, as well as replication of the virus genome (viral RNA) through a complementary RNA intermediate. Virus propagation requires the generation of these RNA species in a controlled manner while competing heavily with the host cell for resources. Influenza virus appropriates host factors to enhance and regulate RdRp activity at every step of RNA synthesis. This review describes such host factors and summarizes our current understanding of the roles they play in viral synthesis of RNA.

中文翻译：

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流感RNA合成的宿主决定因素。

流感病毒是季节性和大流行性呼吸道疾病的主要原因。流感是一种负义单链RNA病毒，它编码自己的RNA依赖性RNA聚合酶（RdRp）进行核酸合成。RdRp催化mRNA合成，以及通过互补RNA中间体复制病毒基因组（病毒RNA）。病毒繁殖需要以受控的方式生成这些RNA，同时与宿主细胞争夺资源。流感病毒在RNA合成的每个步骤中都采用宿主因子来增强和调节RdRp活性。这篇综述描述了这些宿主因素，并总结了我们目前对它们在RNA病毒合成中所发挥作用的理解。