In recent years, the RNA modification N6-methyladenosine (m6A) has been found to play a role in the life cycles of numerous viruses and also in the cellular response to viral infection. m6A has emerged as a regulator of many fundamental aspects of RNA biology. Here, we highlight recent advances in techniques for the study of m6A, as well as advances in our understanding of the cellular machinery that controls the addition, removal, recognition, and functions of m6A. We then summarize the many newly discovered roles of m6A during viral infection, including how it regulates innate and adaptive immune responses to infection. Overall, the goals of this review are to summarize the roles of m6A on both cellular and viral RNAs and to describe future directions for uncovering new functions of m6A during infection.

中文翻译：

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通过 RNA 修饰 N6-甲基腺苷调节病毒感染。

近年来，已发现 RNA 修饰 N6-甲基腺苷 (m6A) 在众多病毒的生命周期以及对病毒感染的细胞反应中发挥作用。m6A 已成为 RNA 生物学许多基本方面的调节剂。在这里，我们重点介绍了 m6A 研究技术的最新进展，以及我们对控制 m6A 添加、去除、识别和功能的细胞机制的理解的进展。然后我们总结了 m6A 在病毒感染过程中的许多新发现的作用，包括它如何调节对感染的先天性和适应性免疫反应。总的来说，这篇综述的目的是总结 m6A 在细胞和病毒 RNA 上的作用，并描述在感染过程中发现 m6A 新功能的未来方向。