The most recent work in the field of model-based design of catalytic reactors with a special focus on the multi-level reactor design (MLRD) methodology is reviewed. The key idea of this method is to track a fluid element on its way through the — not yet specified — reactor and to optimize the reaction conditions along its way by providing the necessary material and energy fluxes. On the basis of these optimal flux profiles novel reactor concepts tailored to the needs of the reaction system can be derived and analyzed. Recent advances and extensions to handle the specifics of reaction systems with different complexity are presented. The MLRD approach enables the predictive determination of the best reaction concept considering highly innovative process intensification options. Thereby, this method provides a key stone for the development of more economical and more sustainable chemical reactors and processes of the future.

审查了基于模型的催化反应器设计领域的最新工作，特别关注多级反应器设计（MLRD）方法。该方法的关键思想是跟踪流体元素通过（尚未指定）反应器的过程，并通过提供必要的材料和能量通量来优化其沿途的反应条件。在这些最佳通量分布的基础上，可以推导和分析适合于反应系统需求的新型反应器概念。提出了用于处理具有不同复杂性的反应系统的细节的最新进展和扩展。MLRD方法考虑到高度创新的工艺强化选项，可以预测最佳反应方案。从而，