Losing weight has significant impact on chronic disease management. Orlistat, a lipase inhibitor, has alternative effect for weight controlling. To find more candidates, we conducted a review of chalcone and xanthine derivatives regarding their anti-lipase activity. Eight databases were searched including PubMed, Scopus, Web of Science (ISI), Virtual Health Library (VHL), System for Information on Grey Literature in Europe (SIGLE), Global Health Library (GHL), EMBASE, and Google Scholar in August 2018. We found chalcone scaffold was more effective on lipase inhibition than xanthine scaffold. Among 19 investigated chalcones, only isoliquiritigenin and licuroside demonstrated an effect on preventing weight gain and increase in the total cholesterol and total triglycerides aside apart from their high activity on inhibiting lipase. Effect and type of inhibition of individual chalcones differed depending on their structure. In addition, very few studies investigated xanthine compounds and their activities were inconsistent. We suggest more studies investigate the ability of chalcones and modifying their structure to find out other compounds with higher efficacy.

中文翻译：

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查尔酮和黄嘌呤衍生物对脂肪酶抑制的功效：系统评价。

减肥对慢性病的治疗有重要影响。脂酶抑制剂奥利司他（Orlistat）具有控制体重的替代作用。为了找到更多的候选者，我们对查尔酮和黄嘌呤衍生物的抗脂肪酶活性进行了综述。2018年8月，搜索了八个数据库，包括PubMed，Scopus，Web of Science（ISI），虚拟健康图书馆（VHL），欧洲灰色文献信息系统（SIGLE），全球卫生图书馆（GHL），EMBASE和Google Scholar我们发现查尔酮支架在抑制脂肪酶方面比黄嘌呤支架更有效。在研究的19个查耳酮中，除异硫氰酸加香皂苷和二十二碳五糖苷具有抑制脂肪酶的高活性外，还具有防止体重增加和总胆固醇和总甘油三酯增加的作用。各个查耳酮的抑制作用和抑制类型因其结构而异。另外，很少有研究研究黄嘌呤化合物及其活性不一致。我们建议进行更多研究，研究查耳酮的能力和修饰其结构，以发现具有更高功效的其他化合物。