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Amphetamine Dose-Dependently Decreases and Increases Binge Intake of Fat and Sucrose Independent of Sex.
Obesity ( IF 6.9 ) Pub Date : 2019-09-27 , DOI: 10.1002/oby.22636
Katherine Stuhrman West 1, 2 , Valen Lawson 1, 3 , Andrew M Swanson 1 , Anna I Dunigan 1 , Aaron G Roseberry 1, 2
Affiliation  

Amphetamine was formerly used as a treatment to combat obesity, but amphetamine’s use as an appetite suppressant was discontinued because of its significant abuse potential. Most of the rewarding and reinforcing effects of amphetamine differ by sex, with females showing higher levels of drug intake and amphetamine‐induced motivation, relapse, and locomotion, but it is unknown whether amphetamine’s effects on feeding also differ by sex. Furthermore, previous research on the anorectic effects of amphetamine has been focused primarily on its effects on baseline homeostatic feeding, but it is unknown whether amphetamine also affects hedonic, reward‐related feeding, which is an important factor driving the rise in obesity levels.

中文翻译:

苯丙胺剂量依赖性地减少和增加脂肪和蔗糖的暴饮暴食,而与性别无关。

苯丙胺以前曾被用作抗肥胖药,但由于苯丙胺具有巨大的滥用潜力,因此已停止将其用作食欲抑制剂。苯丙胺的大多数奖励和增强作用因性别而异,雌性显示较高水平的药物摄入和苯丙胺诱导的动机,复发和运动,但尚不清楚苯丙胺对进食的作用是否也因性别而异。此外,先前关于苯丙胺的厌食作用的研究主要集中于苯丙胺对基线体内稳态喂养的影响,但尚不清楚苯丙胺是否也影响享乐性,与奖励有关的喂养,这是推动肥胖症水平上升的重要因素。
更新日期:2019-09-27
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