PURPOSE To characterize changes in nuclear, cortical, and posterior subcapsular lens opacities after selective laser trabeculoplasty (SLT) in Afro-Caribbean eyes with primary open-angle glaucoma (POAG). SETTING Three clinical practices, Saint Lucia and Dominica. DESIGN Prospective case series. METHODS Patients with POAG in the West Indies Glaucoma Laser Study (WIGLS) had 360-degree SLT after medication washout. No antiinflammatory therapy was used after SLT. Nuclear, cortical, and posterior subcapsular lens opacities were graded through dilated pupils using the Lens Opacification Classification System III (LOCS III) at baseline and 12, 24, and 36 months after SLT, with the grader masked to all previous values after baseline assessment. Changes in opacity scores from baseline were evaluated using paired t tests. RESULTS Seventy-two patients (142 phakic eyes) were evaluated. The mean (±SD) baseline LOCS III opacity scores in right eyes and left eyes, respectively, were 2.44 ± 1.23 and 2.40 ± 1.16 (nuclear), 0.39 ± 1.08 and 0.30 ± 0.85 (cortical), and 0.22 ± 0.59 and 0.15 ± 0.36 (posterior subcapsular). Other than a small improvement in bilateral nuclear opacity scores at 12 months, no statistically or clinically significant changes in any opacity score occurred in either eye up to 36 months postoperatively. Three eyes (2.1%) with preexisting lens opacities had cataract surgery for progressive lens changes at 3 months, 21 months, and 26 months, respectively, after SLT. CONCLUSIONS Selective laser trabeculoplasty was not associated with clinically significant changes in nuclear, cortical, or posterior subcapsular lens opacities in glaucomatous Afro-Caribbean eyes. The rate of cataract surgery is consistent with reported rates from longitudinal natural history studies in Caribbean and non-Caribbean populations.

中文翻译：

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非洲裔加勒比地区开角型青光眼患者选择性激光小梁成形术后晶状体的变化；西印度群岛青光眼激光研究（WIGLS）的报告4。

目的鉴定在患有原发性开角型青光眼（POAG）的非洲-加勒比眼睛中进行选择性激光小梁成形术（SLT）后核，皮质和后囊膜下混浊的变化特征。设置三种临床实践，圣卢西亚和多米尼加。设计预期案例系列。方法西印度群岛青光眼激光研究（WIGLS）中的POAG患者在药物冲洗后具有360度SLT。SLT后未使用抗炎治疗。基线，SLT后12、24和36个月，使用镜头不透明分类系统III（LOCS III）通过扩大的瞳孔对核，皮层和后囊膜混浊的不透明度进行分级，而分级后的分级器会掩盖所有以前的值。使用配对t检验评估了不透明度得分相对于基线的变化。结果对72例患者（142只有晶状体眼）进行了评估。右眼和左眼的平均（±SD）基线LOCS III浊度评分分别为2.44±1.23和2.40±1.16（核），0.39±1.08和0.30±0.85（皮层）以及0.22±0.59和0.15± 0.36（后囊下）。除了在12个月时双侧核不透明度评分略有改善外，直至术后36个月，两只眼睛的任何不透明度评分均未发生统计学上或临床上的显着变化。SLT术后3个月，21个月和26个月，三只眼（2.1％）曾有晶状体混浊的患者进行了白内障手术，以进行渐进性晶状体更换。结论选择性激光小梁成形术与核，皮层，或青光眼非裔加勒比眼睛的囊后晶状体混浊。白内障手术的发生率与加勒比和非加勒比地区人口的纵向自然史研究报告的发生率一致。