Nucleoside antibiotics possess various biological activities such as antibacterial, antifungal, anticancer, and herbicidal activities. RIKEN scientists contributed to this area of research with two representative antifungal nucleoside antibiotics, blasticidin S and polyoxin. Blasticidin S was the first antibiotic exploited in agriculture worldwide. Meanwhile, the polyoxins discovered by Isono and Suzuki are still used globally as an agricultural antibiotic. In this review article, the research on nucleoside antibiotics mainly done by Isono and his collaborators is summarized from the discovery of polyoxin to subsequent investigations.

中文翻译：

---

多恶素以外的核苷类抗生素的发现与应用。

核苷类抗生素具有抗菌、抗真菌、抗癌、除草等多种生物活性。RIKEN 科学家用两种具有代表性的抗真菌核苷类抗生素杀稻瘟菌素 S 和多恶素为这一研究领域做出了贡献。杀稻瘟菌素 S 是世界范围内第一种用于农业的抗生素。同时，矶野和铃木发现的多恶素在全球范围内仍被用作农用抗生素。在这篇综述文章中，对主要由 Isono 及其合作者进行的核苷类抗生素研究从多恶素的发现到后续研究进行了总结。