Several studies have reported a positive association between psychological stress and cardiovascular diseases; however, there is scarce evidence about various aspects of life stress, including traumatic, positive, and negative events. We aimed to evaluate the association between various stressful life events and indicators of cardiovascular risk, including the augmentation index. A total of 3276 participants from the Cardiovascular and Metabolic Diseases Etiology Research Center cohort (Mean age: 50.9) were analyzed cross-sectionally. By using the Life Experience Questionnaire, exposures were grouped as a “positive event,” “negative event,” or “traumatic event.” The augmentation index and subclinical atherosclerosis were measured. Multivariate polytomous logistic regression was used. Overall, stressful life events did not show any significant association with any cardiovascular index; however, increased odds ratios were observed between augmentation index quartiles and those who had experienced traumatic events (quartile 4: odds ratio = 1.41, 95% confidence interval = 1.09–1.82). The association remained valid among women when stratified by sex. There was no significant result in men. Traumatic events in women were positively associated with the augmentation index. These findings suggest that more attention should be paid to trauma in the context of increased cardiovascular risk in women.

中文翻译：

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压力性生活事件和增强指数：来自心血管和代谢疾病病因研究中心的结果

几项研究报告了心理压力与心血管疾病之间的正相关关系；然而，关于生活压力的各个方面的证据很少，包括创伤、积极和消极事件。我们旨在评估各种压力性生活事件与心血管风险指标（包括增强指数）之间的关联。对来自心血管和代谢疾病病因研究中心队列的 3276 名参与者（平均年龄：50.9）进行了横断面分析。通过使用生活体验问卷，暴露被分组为“积极事件”、“消极事件”或“创伤性事件”。测量增强指数和亚临床动脉粥样硬化。使用多元多元逻辑回归。全面的，压力性生活事件与任何心血管指数均无显着相关性；然而，在增强指数四分位数和经历过创伤事件的人之间观察到比值比增加（四分位数：比值比 = 1.41，95% 置信区间 = 1.09–1.82）。当按性别分层时，这种关联在女性中仍然有效。在男性中没有显着结果。女性的创伤事件与增强指数呈正相关。这些发现表明，在女性心血管风险增加的情况下，应该更多地关注创伤。当按性别分层时，这种关联在女性中仍然有效。在男性中没有显着结果。女性的创伤事件与增强指数呈正相关。这些发现表明，在女性心血管风险增加的情况下，应该更多地关注创伤。当按性别分层时，这种关联在女性中仍然有效。在男性中没有显着结果。女性的创伤事件与增强指数呈正相关。这些发现表明，在女性心血管风险增加的情况下，应该更多地关注创伤。