Advances in cancer treatment have improved survival; however, local recurrence and metastatic disease—the principal causes of cancer mortality—have limited the ability to achieve durable remissions. Local recurrences arise from latent tumor cells that survive therapy and are often not detectable by conventional clinical imaging techniques. Local recurrence after transarterial embolization (TAE) of hepatocellular carcinoma (HCC) provides a compelling clinical correlate of this phenomenon. In response to TAE‐induced ischemia, HCC cells adapt their growth program to effect a latent phenotype that precedes local recurrence.

中文翻译：

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超极化代谢成像检测在局部治疗中幸存的潜伏肝细胞癌域

癌症治疗的进步提高了生存率；然而，局部复发和转移性疾病——癌症死亡的主要原因——限制了实现持久缓解的能力。局部复发源于治疗后存活的潜伏肿瘤细胞，通常无法通过常规临床成像技术检测到。肝细胞癌 (HCC) 经动脉栓塞 (TAE) 后的局部复发为这种现象提供了令人信服的临床相关性。为了响应 TAE 诱导的缺血，HCC 细胞调整其生长程序以影响局部复发之前的潜在表型。