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Convenient synthesis of racemic 4,4-difluoro glutamic acid derivatives via Michael-type additions of Ni(II)-complex of dehydroalanine Schiff bases
Journal of Fluorine Chemistry ( IF 1.9 ) Pub Date : 2019-09-20 , DOI: 10.1016/j.jfluchem.2019.109376
Yoshinori Tokairin , Vadim A. Soloshonok , Hiroyuki Konno , Hiroki Moriwaki , Gerd-Volker Röschenthaler

Michael-type addition reactions of Ni(II)-complex of a dehydroalanine Schiff base and ethyl bromodifluoroacetate in the presence of copper for the synthesis of racemic 4,4,-difluoroglutamic acid derivatives were developed. These reactions proceeded smoothly and gave the desired product in 80% yield. Furthermore, this procedure is of low cost-structure, operationally convenient, and scalable.



中文翻译:

通过脱氢丙氨酸席夫碱的Ni(II)配合物的Michael型加成反应方便地合成外消旋4,4-二氟谷氨酸衍生物

在铜的存在下,开发了脱氢丙氨酸席夫碱的Ni(II)络合物与溴代二氟乙酸乙酯的Michael型加成反应,用于合成外消旋4,4,-二氟谷氨酸衍生物。这些反应进行顺利,以80%的收率得到所需产物。此外,该过程成本低廉,操作方便且可扩展。

更新日期:2019-09-20
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