Although knowledge regarding the pathogenesis of nonalcoholic fatty liver disease (NAFLD) has profoundly grown in recent decades, the internal restrictive mechanisms remain largely unknown. We have recently reported that the transcription repressor interferon regulatory factor‐2 binding protein 2 (IRF2BP2) is enriched in cardiomyocytes and inhibits pathological cardiac hypertrophy in mice. Notably, IRF2BP2 is abundantly expressed in hepatocytes and dramatically down‐regulated in steatotic livers, whereas the role of IRF2BP2 in NAFLD is unknown.

中文翻译：

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肝脏 IRF2BP2 通过直接抑制 ATF3 的转录减轻非酒精性脂肪肝

尽管近几十年来关于非酒精性脂肪性肝病 (NAFLD) 发病机制的知识有了深刻的发展，但其内部限制机制仍然在很大程度上未知。我们最近报道了转录抑制因子干扰素调节因子 2 结合蛋白 2 (IRF2BP2) 富含心肌细胞并抑制小鼠病理性心脏肥大。值得注意的是，IRF2BP2 在肝细胞中大量表达，在脂肪肝中显着下调，而 IRF2BP2 在 NAFLD 中的作用尚不清楚。