Covering: 2006 to 2019Macrocyclic diamine alkaloids derived from 3-alkyldihydropyridine dimers comprise a diverse and highly complex family of natural products. The macrocyclic and caged structural features of these alkaloids have inspired many creative solutions from the synthetic organic community over the past 30 years. This review will cover the successful synthetic campaigns over the past decade, with a focus on (1) key bond disconnections and advances and (2) remaining challenges and opportunities for innovation within this natural product class.

中文翻译：

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大环二胺生物碱总合成的最新进展。

涵盖范围：2006年至2019年衍生自3-烷基二氢吡啶二聚体的大环二胺生物碱包括各种高度复杂的天然产物。在过去的30年中，这些生物碱的大环和笼状结构特征启发了合成有机社区的许多创新解决方案。这篇综述将涵盖过去十年中成功的合成运动，重点是（1）关键键的断开连接和改进，以及（2）在该天然产品类别中尚存的挑战和创新机会。