Glutathione transferases (GSTs) represent a widespread enzyme superfamily in eukaryotes and prokaryotes catalyzing different reactions with endogenous and xenobiotic substrates such as organic pollutants. The latter are often found together with metal contamination in the environment. Besides performing of essential functions, GSTs protect cells by conjugation of glutathione with various reactive electrophiles. The interference of toxic metals with this functionality of GSTs may have unpredictable toxicological consequences for the organisms. In this review results from the recent literature are summarized and discussed describing the ability of metals to inhibit intracellular detoxification processes in animals and plants.

中文翻译：

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金属对动植物谷胱甘肽转移酶的抑制作用。

谷胱甘肽转移酶（GST）代表真核生物和原核生物中广泛的酶超家族，催化与内源性和异源性底物（例如有机污染物）的不同反应。后者经常与环境中的金属污染一起被发现。除执行基本功能外，GST还通过谷胱甘肽与各种反应性亲电试剂的结合来保护细胞。GST的这种功能对有毒金属的干扰可能会对生物体产生不可预测的毒理学后果。在这篇综述中，总结并讨论了来自最近文献的结果，这些结果描述了金属抑制动物和植物中细胞内解毒过程的能力。