当前位置: X-MOL 学术Nat. Rev. Neurol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Post-traumatic headache: epidemiology and pathophysiological insights.
Nature Reviews Neurology ( IF 38.1 ) Pub Date : 2019-09-16 , DOI: 10.1038/s41582-019-0243-8
Håkan Ashina 1 , Frank Porreca 2, 3 , Trent Anderson 4 , Faisal Mohammad Amin 1 , Messoud Ashina 1 , Henrik Winther Schytz 1 , David W Dodick 3
Affiliation  

Post-traumatic headache (PTH) is a highly disabling secondary headache disorder and one of the most common sequelae of mild traumatic brain injury, also known as concussion. Considerable overlap exists between PTH and common primary headache disorders. The most common PTH phenotypes are migraine-like headache and tension-type-like headache. A better understanding of the pathophysiological similarities and differences between primary headache disorders and PTH could uncover unique treatment targets for PTH. Although possible underlying mechanisms of PTH have been elucidated, a substantial void remains in our understanding, and further research is needed. In this Review, we describe the evidence from animal and human studies that indicates involvement of several potential mechanisms in the development and persistence of PTH. These mechanisms include impaired descending modulation, neurometabolic changes, neuroinflammation and activation of the trigeminal sensory system. Furthermore, we outline future research directions to establish biomarkers involved in progression from acute to persistent PTH, and we identify potential drug targets to prevent and treat persistent PTH.

中文翻译:

创伤后头痛:流行病学和病理生理学见解。

创伤后头痛(PTH)是一种高度致残的继发性头痛疾病,是轻度颅脑损伤(也称为脑震荡)的最常见后遗症之一。PTH与常见的原发性头痛疾病之间存在相当多的重叠。最常见的PTH表型是偏头痛样头痛和紧张型头痛。更好地了解原发性头痛疾病与PTH之间的病理生理相似性和差异可能会发现PTH的独特治疗靶标。尽管已经阐明了PTH的潜在潜在机制,但我们的理解仍然存在很大的空白,需要进一步研究。在本综述中,我们描述了来自动物和人类研究的证据,这些证据表明PTH的发展和持续存在多种潜在机制。这些机制包括受损的递减调制,神经代谢变化,神经炎症和三叉神经感觉系统的激活。此外,我们概述了未来的研究方向,以建立参与从急性PTH到持久性PTH进程的生物标记物,并确定预防和治疗持久性PTH的潜在药物靶标。
更新日期:2019-09-16
down
wechat
bug