Tumor metastasis is a major factor of high recurrence and mortality in hepatocellular carcinoma (HCC), but its underlying mechanism remains elusive. We report that PDZ and LIM domain protein 1 (PDLIM1) is significantly down‐regulated in metastatic human HCC tissues, which predicts unfavorable prognosis, suggesting that PDLIM1 may play an important inhibitory role during HCC metastasis.

中文翻译：

---

PDLIM1通过激活Hippo信号抑制肝细胞癌的肿瘤转移

肿瘤转移是肝细胞癌（HCC）高复发率和死亡率的主要因素，但其潜在机制尚不清楚。我们报告说，PDZ 和 LIM 结构域蛋白 1（PDLIM1）在转移性人类 HCC 组织中显着下调，这预示着不良预后，表明 PDLIM1 可能在 HCC 转移过程中发挥重要的抑制作用。