Activated hepatocytes are hypothesized to be a major source of signals that drive cirrhosis, but the biochemical pathways that convert hepatocytes into such a state are unclear. We examined the role of the Hippo pathway transcriptional coactivators Yes‐associated protein (YAP) and transcriptional coactivator with PDZ‐binding motif (TAZ) in hepatocytes to facilitate cell–cell interactions that stimulate liver inflammation and fibrosis.

中文翻译：

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肝细胞应激增加肝细胞中 YAP 和 TAZ 的表达以促进实质炎症和纤维化

假设激活的肝细胞是导致肝硬化的主要信号来源，但将肝细胞转化为这种状态的生化途径尚不清楚。我们研究了 Hippo 通路转录共激活因子 Yes 相关蛋白 (YAP) 和具有 PDZ 结合基序 (TAZ) 的转录共激活因子在肝细胞中的作用，以促进刺激肝脏炎症和纤维化的细胞-细胞相互作用。