The assembly of amphiphilic block copolymers in well-defined polymer nanoparticles is an intricate interplay between polymer composition, method of assembly and the properties of the organic solvent used to dissolve the polymer building blocks. Remarkably, the role of organic solvent composition has been much less studied in comparison to the other two parameters. Here we have systematically investigated the effect of organic solvent composition, namely, the ratio between tetrahydrofuran and dioxane, on the self-assembly of PEG-PDLLA copolymers into polymer vesicles and their subsequent shape change in different topologies. Uncovering such physical basis unlocks new opportunities for the development of complex nanoparticles without the need of extended polymer engineering processes.

中文翻译：

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通过定制溶剂-聚合物相互作用， 研究聚（乙二醇）-b-聚（d，l-丙交酯）（PEG-PDLLA）聚合物囊泡的自组装和形状转变†

两性嵌段共聚物在界限分明的聚合物纳米颗粒中的组装是聚合物组成，组装方法和用于溶解聚合物构件的有机溶剂的性质之间的复杂相互作用。值得注意的是，与其他两个参数相比，有机溶剂组合物的作用还很少研究。在这里，我们系统地研究了有机溶剂组成（即四氢呋喃和二恶烷之间的比例）对PEG-PDLLA共聚物自组装成聚合物囊泡及其随后在不同拓扑结构中的形状变化的影响。揭露这种物理基础无需复杂的聚合物工程流程，即可为开发复杂的纳米粒子开辟新的机会。