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Expression pattern of co-inhibitory molecules on CMV-specific T-cells in lung transplant patients.
Clinical Immunology ( IF 8.6 ) Pub Date : 2019-09-06 , DOI: 10.1016/j.clim.2019.108258
Vasiliki Bessa 1 , Ming Sun 2 , Maike Meier 3 , Ye Zeng 2 , Shilei Xu 2 , Sebastian Dolff 3 , Urte Sommerwerck 4 , Johannes Korth 2 , Christian Taube 1 , Clemens Aigner 5 , Markus Kamler 6 , Andreas Kribben 2 , Monika Lindemann 7 , Oliver Witzke 3 , Benjamin Wilde 2
Affiliation  

OBJECTIVES Cytomegalovirus infection (CMVi) occurs frequently in transplant patients. Co-inhibitory molecules on CMV-specific T-cells (TCMV) in patients after lung transplantation were investigated. METHODS 59 lung transplant patients were stratified according to anti-CMV serostatus at time of transplantation. The co-inhibitors Programmed-Death-Receptor-1 (PD1) and B-and-T-Lymphocyte-Attenuator (BTLA) were detected on TCMV by flow cytometry (FACS). RESULTS TCMV were detectable in CMV sero-positive patients (R+) and in CMV sero-negative patients with a lung graft of a CMV sero-positive donor (D+/R-); in both cases, the frequency of TCMV was higher than in healthy controls (HC). PD-1 on TCMV was increased in D+/R+ and D+/R- patients as compared to HC. BTLA was significantly enhanced on TCMV of D+/R- patients vs. HC. R+ patients with CMV reactivation in the past had an increased fraction of BTLA+ TCMV. CONCLUSION In conclusion, the expression pattern of co-inhibitory molecules on TCMV is altered in patients after lung transplantation.

中文翻译:

肺移植患者CMV特异性T细胞上共抑制分子的表达模式。

目的在移植患者中经常发生巨细胞病毒感染(CMVi)。研究了肺移植后患者对CMV特异性T细胞(TCMV)的共抑制分子。方法对59例肺移植患者在移植时根据其抗CMV血清状态进行分层。通过流式细胞术(FACS)在TCMV上检测到了共抑制因子Program-Death-Receptor-1(PD1)和B-和T-淋巴细胞-Attenuator(BTLA)。结果CMMV血清阳性患者(R +)和CMV血清阳性供者肺移植的CMV血清阴性患者(D + / R-)均可检测到TCMV;在这两种情况下,TCMV的频率均高于健康对照(HC)。与HC相比,D + / R +和D + / R-患者中TCMV上的PD-1升高。与HC相比,D + / R-患者的TCMV BTLA显着增强。过去接受过CMV激活的R +患者的BTLA + TCMV比例增加。结论总的来说,肺移植术后患者中TCMV共抑制分子的表达模式发生了改变。
更新日期:2019-09-06
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