The Wnt/β‐catenin signaling pathway has a well‐described role in liver pathobiology. Its suppression was recently shown to decrease bile acid (BA) synthesis, thus preventing the development of cholestatic liver injury and fibrosis after bile duct ligation (BDL).

中文翻译：

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Wnt/β-Catenin 信号在 Mdr2 KO 小鼠胆汁淤积性肝病模型中发挥保护作用

Wnt/β-连环蛋白信号通路在肝脏病理学中具有明确的作用。最近显示，其抑制可减少胆汁酸（BA）的合成，从而防止胆管结扎（BDL）后胆汁淤积性肝损伤和纤维化的发展。