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Differences in Duration and Degree of Cytomegalovirus DNAemia Observed With Two Standardized Quantitative Nucleic Acid Tests and Implications for Clinical Care.
The Journal of Infectious Diseases ( IF 6.4 ) Pub Date : 2020-01-02 , DOI: 10.1093/infdis/jiz452
Atibordee Meesing 1, 2 , Jeffrey J Germer 3 , Joseph D Yao 3 , Michelle L Gartner 3 , Benjamin J Digmann 3 , Raymund R Razonable 1, 4
Affiliation  

Cytomegalovirus (CMV) viral loads overall were 0.29 log IU/mL higher with cobas CMV for use on the cobas 6800/8800 System (cobas CMV) compared with Cobas AmpliPrep/Cobas TaqMan CMV Test (CAP/CTM CMV). Cytomegalovirus DNAemia was detected 11.5 days earlier by cobas CMV, whereas clearance was delayed by 12.8 days. Cytomegalovirus remained detectable by cobas CMV in 44.2% of patients at the time of viral clearance as determined by CAP/CTM CMV. Undetectable viral load by cobas CMV at end of treatment was associated with reduced risk for retreatment (odds ratio, 0.26; 95% confidence interval, 0.04-0.99; P = .05). The use of different quantitative cytomegalovirus nucleic acid tests may affect direct patient care as a result of significant differences in reporting the degree of CMV DNAemia and the time to first detection and clearance of CMV DNAemia.

中文翻译:

用两种标准化的定量核酸测试观察到的巨细胞病毒DNA血症持续时间和程度的差异及其对临床护理的意义。

与Cobas AmpliPrep / Cobas TaqMan CMV测试(CAP / CTM CMV)相比,用于cobas 6800/8800系统(cobas CMV)的cobas CMV总体而言,巨细胞病毒(CMV)病毒载量高出0.29 log IU / mL。cobas CMV在11.5天之前检测到巨细胞病毒DNA血症,而清除延迟了12.8天。根据CAP / CTM CMV的测定,在病毒清除时,cobas CMV仍可在44.2%的患者中检测到巨细胞病毒。在治疗结束时,cobas CMV无法检测到病毒载量与降低再治疗风险相关(赔率,0.26; 95%置信区间,0.04-0.99; P = 0.05)。由于报告CMV DNAemia的程度以及首次检测和清除CMV DNAemia的时间存在显着差异,因此使用不同的定量巨细胞病毒核酸测试可能会影响直接的患者护理。
更新日期:2019-12-30
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