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Gene-lifestyle interaction on risk of type 2 diabetes: A systematic review.
Obesity Reviews ( IF 8.9 ) Pub Date : 2019-09-02 , DOI: 10.1111/obr.12921
Stefan Dietrich 1 , Simone Jacobs 1 , Ju-Sheng Zheng 2, 3 , Karina Meidtner 1, 4 , Lukas Schwingshackl 5 , Matthias B Schulze 1, 4, 6
Affiliation  

The pathophysiological influence of gene‐lifestyle interactions on the risk to develop type 2 diabetes (T2D) is currently under intensive research. This systematic review summarizes the evidence for gene‐lifestyle interactions regarding T2D incidence. MEDLINE, EMBASE, and Web of Science were systematically searched until 31 January 2019 to identify publication with (a) prospective study design; (b) T2D incidence; (c) gene‐diet, gene‐physical activity, and gene‐weight loss intervention interaction; and (d) population who are healthy or prediabetic. Of 66 eligible publications, 28 reported significant interactions. A variety of different genetic variants and dietary factors were studied. Variants at TCF7L2 were most frequently investigated and showed interactions with fiber and whole grain on T2D incidence. Further gene‐diet interactions were reported for, eg, a western dietary pattern with a T2D‐GRS, fat and carbohydrate with IRS1 rs2943641, and heme iron with variants of HFE. Physical activity showed interaction with HNF1B, IRS1, PPARγ, ADRA2B, SLC2A2, and ABCC8 variants and weight loss interventions with ENPP1, PPARγ, ADIPOR2, ADRA2B, TNFα, and LIPC variants. However, most findings represent single study findings obtained in European ethnicities. Although some interactions have been reported, their conclusiveness is still low, as most findings were not yet replicated across multiple study populations.

中文翻译:

基因-生活方式对 2 型糖尿病风险的相互作用:系统评价。

基因-生活方式相互作用对 2 型糖尿病 (T2D) 风险的病理生理影响目前正在深入研究中。本系统综述总结了有关 T2D 发病率的基因-生活方式相互作用的证据。直到 2019 年 1 月 31 日,对 MEDLINE、EMBASE 和 Web of Science 进行了系统搜索,以确定具有 (a) 前瞻性研究设计的出版物;(b) T2D 发病率;(c) 基因-饮食、基因-体力活动和基因-减肥干预相互作用;(d) 健康或糖尿病前期的人群。在 66 篇符合条件的出版物中,28 篇报告了显着的相互作用。研究了各种不同的遗传变异和饮食因素。TCF7L2 的变体最常被研究并显示与纤维和全谷物的相互作用对 T2D 发病率的影响。报告了进一步的基因-饮食相互作用,例如具有 T2D-GRS 的西方饮食模式、具有IRS1 rs2943641 的脂肪和碳水化合物以及具有HFE变体的血红素铁。体力活动显示出与HNF1BIRS1PPARγADRA2BSLC2A2ABCC8变体的相互作用以及与ENPP1PPARγADIPOR2ADRA2BTNFαLIPC 的减肥干预变种。然而,大多数研究结果代表在欧洲种族中获得的单一研究结果。尽管已经报道了一些相互作用,但它们的结论性仍然很低,因为大多数发现尚未在多个研究人群中重复。
更新日期:2019-09-02
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