The adaptor protein CARD9 plays an important role in anti-fungal immunity responses, linking detection of fungi by surface receptors to activation of the transcription factor nuclear factor κB (NF-κB). Recent studies indicate that CARD9 also plays different but vital roles during the development of colitis-associated colorectal cancer (CAC). This review summarizes the current understanding of CARD9 functions in CAC, and we discuss its potentially carcinogenic mechanisms.

中文翻译：

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衔接蛋白CARD9在结肠炎相关癌症中的作用

衔接蛋白CARD9在抗真菌免疫反应中起重要作用，将表面受体对真菌的检测与转录因子核因子κB（NF-κB）的激活联系起来。最近的研究表明，CARD9在结肠炎相关的大肠癌（CAC）的发展过程中也发挥着不同但至关重要的作用。这篇综述总结了目前对CAC中CARD9功能的理解，并讨论了其潜在的致癌机制。