The present study employed an antibody array that simultaneously detects 174 cytokines to identify cytokines involved in the development of macrophage activation syndrome (MAS) associated with systemic lupus erythematosus (SLE) with a view to elucidating potential predictive markers. Eight SLE patients, including four with MAS, were analyzed. Levels of 31 cytokines were significantly elevated in the MAS phase compared with those in the active phase of SLE. Among these cytokines, the MAS/active phase ratios of CXCL9 and soluble tumor necrosis factor receptor II (sTNFR-II) were highest. Elevated serum CXCL9 and sTNFR-II levels during the MAS phase were confirmed by ELISA and were strongly correlated with other inflammatory markers, reflecting the disease activity of MAS associated with SLE. These results highlight the clinical significance of serum CXCL-9 and sTNFR-II levels, and indicate they may be useful biomarkers for the diagnosis of MAS associated with SLE.

中文翻译：

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与系统性红斑狼疮相关的巨噬细胞活化综合征患者的广泛血清生物标志物分析。

本研究采用了一种抗体阵列，该抗体阵列可同时检测174种细胞因子，以鉴定与系统性红斑狼疮（SLE）相关的巨噬细胞活化综合征（MAS）的发展所涉及的细胞因子，以阐明潜在的预测标记。分析了8例SLE患者，包括4例MAS。与SLE活动期相比，MAS期的31种细胞因子水平显着升高。在这些细胞因子中，CXCL9和可溶性肿瘤坏死因子受体II（sTNFR-II）的MAS /活性相比率最高。ELISA证实了MAS阶段的血清CXCL9和sTNFR-II水平升高，并且与其他炎症标记密切相关，反映了与SLE相关的MAS的疾病活动。