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Adequate expression of Globin1 is required for development and maintenance of nervous system in Drosophila.
Molecular and Cellular Neuroscience ( IF 3.5 ) Pub Date : 2019-08-28 , DOI: 10.1016/j.mcn.2019.103398
Nisha 1 , Prerna Aggarwal 1 , Surajit Sarkar 1
Affiliation  

Neurogenesis is driven by spatially and temporally regulated proliferation of neuronal progenitor cells that generates enormous number of assorted neurons to drive the complex behavior of an organism. Drosophila nervous system provides an advantageous model for identification and elucidation of the functional significance of the novel gene(s) involved in neurogenesis. The present study attempts to investigate the role(s) of globin1 (glob1) in the development and maintenance of the nervous system in Drosophila. It is increasingly clear now that globin genes play important role(s) in the various biological phenomena. The vertebrate neuroglobin has been reported to profoundly express in neuronal tissues and provides neuroprotection. We noted ubiquitous presence of Glob1 in the developing neuronal tissues with enhanced concentration throughout the VNC which comprises of midline cell clusters, which subsequently forms numerous types of progenitor cells and finally differentiate into specific neurons of the nervous system. Ubiquitous or pan-neuronal downregulation of glob1 causes partial lethality and mis-positioning of various neural-progenitor cells present in the embryonic midline cell clusters. Subsequently, profound expression of Glob1 was noted in the outer proliferation center of larval brain and photoreceptor axons of optic stalk. The overall arrangement of photoreceptor axons and stereotype positioning of neuroblast cells present in the central region of the brain were severally affected due to reduced expression of glob1. In addition, such larvae and surviving adults develop significant neuro-muscular disabilities. For the first time, our study suggests a novel role of glob1 in development and maintenance of the nervous system adding a new dimension to the functional significance of the multi-tasking glob1 gene in Drosophila.

中文翻译:

果蝇中神经系统的发育和维持需要Globin1的充分表达。

神经发生是由神经元祖细胞的时空调节增殖驱动的,神经元祖细胞产生大量的各种神经元来驱动生物体的复杂行为。果蝇神经系统为鉴定和阐明涉及神经发生的新基因的功能意义提供了有利的模型。本研究试图调查果蝇中globin1(glob1)在神经系统发育和维持中的作用。现在越来越清楚的是,球蛋白基因在各种生物学现象中起着重要的作用。据报道,脊椎动物的神经球蛋白在神经元组织中深入表达并提供神经保护作用。我们注意到Glob1在发育中的神经元组织中普遍存在,其浓度在整个VNC中的浓度有所增加,其中包括中线细胞簇,随后形成多种类型的祖细胞,最后分化为神经系统的特定神经元。glob1的普遍存在或泛神经元下调会导致部分致死性和胚胎中线细胞簇中存在的各种神经祖细胞的错位。随后,在幼虫脑的外部增殖中心和视杆的光感受器轴突中发现了Glob1的深入表达。由于glob1的表达减少,分别影响大脑中部的感光细胞轴突的整体排列和成神经细胞的定型定位。此外,这样的幼虫和存活的成年人会发展出明显的神经肌肉残疾。首次,我们的研究提出了glob1在神经系统发育和维持中的新作用,为果蝇中多任务glob1基因的功能意义添加了新的维度。
更新日期:2019-08-28
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