A new mouse model of Parkinson's disease (PD) demonstrates α-synuclein pathology spreading from the gut to the brain via the vagus nerve (Kim et al., Neuron, 2019). The pathology is associated with motor and non-motor behavioral deficits in wild-type mice. These findings support the idea that the gut could be a starting point for PD.

中文翻译：

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肠道和帕金森研究中的大量运动

一种新的帕金森病 (PD) 小鼠模型表明，α-突触核蛋白病理学通过迷走神经从肠道扩散到大脑（Kim 等，Neuron，2019）。该病理与野生型小鼠的运动和非运动行为缺陷有关。这些发现支持肠道可能是 PD 起点的观点。