Yeast bioactives (YB) may stimulate broiler breeders (BB) to increase deposition of immunoglobulins (Ig) in eggs. We investigated the effects of feeding YB (mixture of derivatives from whole yeast subjected to enzymatic hydrolysis) to BB and/or their offspring on growth performance, gut development, and immune function in broiler chickens challenged with Eimeria. The BB (Ross 708 ♀ and Ross ♂) were assigned to 2 groups (60 ♀ and 10 ♂) and fed basal or basal diet supplemented with 500 g of YB/Mt. A total of 250 fertile eggs per treatment were collected, incubated, hatched, and sexed. Additional egg samples were analyzed for IgA and IgY contents. A total of 160 broiler chicks (80 ♀ and 80 ♂) from each breeder experimental group were placed in cages based on sex and BW resulting in 32 cages for each BB treatment group. Cages (16 per BB treatment group) were allocated to basal broiler chick diet or basal diet supplemented with 500 g of YB/Mt. On day 9, half of each BB by broiler chick dietary treatments was challenged with 1 mL of Eimeria culture (100,000 oocysts of Eimeria acervulina and 25,000 oocysts of Eimeria maxima). On day 14, all birds were necropsied for intestinal lesion scores and samples. Feeding YB to BB increased (P < 0.05) IgA concentration in egg yolk. Eimeria challenge decreased (P < 0.05) pancreas weight, jejunal villus height (VH), and growth performance but increased spleen weight, intestinal mass and jejunal mucosa IgA concentration. Independent of Eimeria challenge, feeding YB to BB and/or to chicks resulted in higher (P < 0.001) jejunal VH compared with feeding it to BB only or not at all. In conclusion, Eimeria challenge reduced growth performance and had negative effects on indices of intestinal function and health. Feeding YB to BB increased deposition of IgA in hatching eggs and improved jejunal VH independent of Eimeria challenge when fed to BB and/or to broiler chicks.

中文翻译：

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向肉鸡饲养者和/或其后代饲喂酵母生物活性物质对用艾美球虫攻击的肉鸡的生长性能，肠道发育和免疫功能的影响。

酵母生物活性物质（YB）可能会刺激肉鸡育种家（BB）增加鸡蛋中免疫球蛋白（Ig）的沉积。我们调查了饲喂YB（经过酶水解的全酵母衍生物混合物）到BB和/或它们的后代对艾美球虫攻击的肉鸡的生长性能，肠道发育和免疫功能的影响。将BB（罗斯708♀和罗斯assigned）分为2组（60♀和10♂），并饲喂补充500 g YB / Mt的基础或基础饮食。每次处理共收集，孵化，孵化和定性250个可育卵。分析另外的卵样品的IgA和IgY含量。每个繁殖者实验组共将160只肉鸡（80♀和80♂）按性别和体重划分为笼子，每个BB处理组为32笼子。将笼子（每个BB治疗组16个）分配给基础肉鸡雏鸡日粮或补充500 g YB / Mt的基础日粮。在第9天，通过肉鸡雏鸡饮食处理的每个BB的一半用1mL艾美球虫培养物（100,000个艾美球虫卵囊和25,000个最大艾美球虫卵囊）攻击。在第14天，对所有鸡进行尸检，以检查肠道损伤分数和样品。将YB饲喂给BB可使蛋黄中的IgA浓度增加（P <0.05）。艾美球虫攻击降低了（P <0.05）胰腺重量，空肠绒毛高度（VH）和生长性能，但脾脏重量，肠质量和空肠黏膜IgA浓度增加。独立于艾美球虫攻击，将BB和/或小鸡饲喂YB导致的空肠VH高于（仅或完全不饲喂BB）空肠VH。综上所述，艾美球虫挑战降低了生长性能，并对肠道功能和健康指数产生了负面影响。向BB饲喂YB会增加孵化卵中IgA的沉积，并改善空肠VH的水平，与饲喂BB和/或肉鸡的艾美球虫攻击无关。